报告题目：A delay differential equation model for metabolic feedback among glucose, insulin and glucagon, and some thoughts on dual pump artificial pancreas

报告时间：2024年6月28日（周五）上午10：00

报告地点：9号楼景中师范中心

报告人：李嘉旭

报告人单位：路易维尔大学

报告人简介：

李嘉旭，博士，美国路易维尔大学教授。1996年获美国亚利桑那州立大学计算机科学硕士学位，2004年获美国亚利桑那州立大学数学博士学位。自2007年8月起在美国路易维尔大学数学系任助理教授，副教授，教授。李嘉旭教授主要从事于动力系统、泛函微分方程和数学生物学的研究，特别集中于基因转化，代谢系统及糖尿病的研究，任Frontier Systems Biology和Mathematical Bioscience and Engineering编委。在主要专业杂志发表有影响力的多篇论文，参与美国卫生研究院、能源部项目，并主持其子项目。研究成果处于国际领先水平，被生物学家和控制专家所应用。在2007年8月之前，李嘉旭教授曾在美国高科技工业领域工作十余年，历任程序员、工程师、高级工程师、资深高级工程师，从事数据库和控制软件的研发工作。

报告主要内容：

Glucose, insulin, and glucagon together form a complete endocrine metabolic feedback loop. Most existing modeling work pertaining to this loop focuses mainly on the regulations between glucose and insulin. The role of glucagon in these works is summarized by hepatic glucose production(HGP) dependent solely on insulin levels. In this talk, we carefully analyze the secretion of glucagon, its role in HGP, and its interactions with insulin, and then formulate a dynamical system model to further analyze its effects in balancing blood sugar levels. The presence of glucagon allows us to examine the impacts of HGP governed by insulin and glucagon separately. This reveals insight about how a very recent concept, glucagon resistance, can affect blood glucose levels and lead to rampant glucagon production and consequently blood sugar levels. We also show that a form of insulin resistance in hepatic cells can lead to excess insulin secretion, a characteristic of type 2 diabetes mellitus. We also present some thoughts on modeling the feedback loop in a dual pump artificial pancreas.

  邀请单位：数学与统计学院