报告题目：Pharmacokinetic models with cooperative saturable drug-target interaction

报告时间：2021年11月19日（周六）上午8:40------9:20

报告地点： 961868332（腾讯会议）

报告人：吴孝钿副教授

报告人单位：上海海事大学

报告人简介：

    2000年西北工业大学本科，2003年复旦大学硕士，2013年加拿大约克大学应用数学博士；于2013-2018年间断性在加拿大西安大略大学应用数学系和蒙特利尔大学药学院从事博士后工作；主要从事虫媒传播疾病的数学建模与研究，以及定量系统药理学中的药物动力学的建模分析研究；在《Environmental Health Perspectives》、《Journal of Pharmacokinetics and Pharmacodynamics》、《Journal of Mathematical Biology》、《Journal of Theoretical Biology》、《Bulletin of Mathematical Biology》等国际生物数学主流期刊和药学专业期刊等发表论文三十篇，其中基于天气变化的莱姆病传播媒介风险图和药物动力学研究成果分别受到加拿大公共卫生局和Wolfram Mathematics公司的关注。曾主持完成国家自科青年基金（NSFC）和海外加拿大魁北克省自然科学博士后基金（FRQNT）各一项，目前主持国家自然科学基金面上项目一项。

报告摘要：

Cooperative saturable kinetics between drug molecular and target interaction is very common. The elimination is empirically exhibited by sigmoidal type of Hill equation, which results in the nonlinear elimination property which has been recognized as one of the major issues compromising the drug efficacy and toxicity. In this talk, I will introduce the background of research in drug discovery and drug development, and the studied pharmacokinetic models with drugs exhibiting cooperative drug-target interaction. As a result, the complete solutions of time course of drug concentration and several important pharmacological parameters including clearance, elimination half-life and drug exposure are presented. These model-based findings theoretically elucidate important pharmacokinetic issues and provide guidance for the rational drug designs. These are jointed works with Prof. Jun Li and Fahima Nekka at University of Montreal in Canada.

邀请单位：数学与统计学院